PF3D7_0214300

Genome location: Pf3D7_02_v3:577,433..586,702(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.33	0.85
Trophozoite	possibly expressed	0.25	0.88
Schizont	not expressed	0.11	0.93
Gametocyte	not expressed	1.21	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0214300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.214 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96223

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_123204

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	100	53	105
disruptive	232	453	200	481
missense	129	332	146	353

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	39	187	68	121
disruptive	352	793	299	637
missense	209	566	222	404

PlasmoDB Total SNPs: 932

Non-coding: 216 | Synonymous: 340 | Nonsynonymous: 376 | Stop Codon: 0

Protein Information

Protein Length: 2500 | Molecular Weight (kDa): 293.887

UniProt ID(s): O96223

PDB ID(s): None

Isoelectric Point: 6.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097