PF3D7_0214400

Genome location: Pf3D7_02_v3:586,717..589,640(-)

Genome classification: Core

Function and Localization

Product Description: protein LTV1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0005634	nucleus
Component	GO:0030688	preribosome, small subunit precursor
Process	GO:0042274	ribosomal small subunit biogenesis
Process	GO:0000056	ribosomal small subunit export from nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.20	0.49
Trophozoite	expressed	0.77	0.61
Schizont	expressed	0.24	0.86
Gametocyte	expressed	1.17	0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0214400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.227 | MFS: -2.768 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0311200)

Relative Growth Rate: 0.12 ± 0.07
Confidence: 6.78

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96224

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132248

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	33	13	32
disruptive	32	95	51	95
missense	20	81	44	77

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	49	28	27
disruptive	58	188	87	173
missense	36	136	78	127

PlasmoDB Total SNPs: 173

Non-coding: 105 | Synonymous: 49 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 619 | Molecular Weight (kDa): 73.716

UniProt ID(s): O96224

PDB ID(s): None

Isoelectric Point: 5.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007307	Low temperature viability protein Ltv1
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104