Product Description: serine/threonine protein kinase STK2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0004672 | protein kinase activity |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.54 | 0.84 |
| Trophozoite | possibly expressed | 0.09 | 0.95 |
| Schizont | expressed | 0.71 | 0.75 |
| Gametocyte | possibly expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0214600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.581 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0311400)
Modification: Disrupted | RMgm-4677
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96226
"Best" AlphaFill ligand hit: BU1 (1,4-butanediol, Local RMSD=0.11) with 7XZQ (Global RMSD=3.25)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 78 | 49 | 98 |
| disruptive | 64 | 292 | 147 | 334 |
| missense | 41 | 247 | 132 | 286 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 156 | 78 | 115 |
| disruptive | 149 | 553 | 242 | 461 |
| missense | 81 | 462 | 205 | 349 |
PlasmoDB Total SNPs: 230
Non-coding: 56 | Synonymous: 101 | Nonsynonymous: 73 | Stop Codon: 0
Protein Length: 1714 | Molecular Weight (kDa): 204.289
UniProt ID(s): O96226
PDB ID(s): None
Isoelectric Point: 9.85
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR008271 | Serine/threonine-protein kinase, active site |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| PFam | PF00069 | Protein kinase domain |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25326719 | Phylogenetic analysis of STK gene family and Usp domain in maize | Zhou T, Fan M, ..., Feng L | 10.1007/s11033-014-3728-y |
| 33259860 | Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdxmice | Pryce BR, Labreche C, ..., Sabourin LA | 10.1016/j.bbamcr.2020.118917 |
| 27667697 | A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages | Depardieu F, Didier JP, ..., Bikard D | 10.1016/j.chom.2016.08.010 |
| 28986443 | Competitive Ability of Maize Pollen Grains Requires Paralogous Serine Threonine Protein Kinases STK1 and STK2 | Huang JT, Wang Q, ..., Dooner HK | 10.1534/genetics.117.300358 |
| 23495751 | Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity | Lemeer S, Zorgiebel C, ..., Kuster B | 10.1021/pr301073j |
| 25054004 | Cell culture of human gingival fibroblasts, oral cancer cells and mesotheliomacells with serum-free media, STK1 and STK2 | Tsugeno Y, Sato F, Muragaki Y, Kato Y | 10.3892/br.2014.306 |
| 33961052 | The Ste20-like kinase - a Jack of all trades | Garland B, Delisle S, ..., Sabourin LA | 10.1242/jcs.258269 |
| 29228724 | Transforming growth factor beta-induced epithelial to mesenchymal transitionrequires the Ste20-like kinase SLK independently of its catalytic activity | Conway J, Al-Zahrani KN, ..., Sabourin LA | 10.18632/oncotarget.21928 |
| 19252397 | [Effectivity of the novel serum-free medium STK2 for proliferating humanmesenchymal stem cells] | Ishikawa I, Sawada R, ..., Tsuchiya T | 10.1248/yakushi.129.381 |