PF3D7_0214800

Genome location: Pf3D7_02_v3:603,261..609,873(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.09	0.54
Trophozoite	expressed	0.54	0.70
Schizont	expressed	0.38	0.79
Gametocyte	not expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0214800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.051 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0311600)

Relative Growth Rate: 0.03 ± 0.06
Confidence: 7.04

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_0311600)

Modification: Tagged | RMgm-4357

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96228

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532626

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	53	34	78
disruptive	47	156	67	188
missense	36	139	59	160

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	106	55	86
disruptive	91	314	143	337
missense	59	258	125	216

PlasmoDB Total SNPs: 354

Non-coding: 202 | Synonymous: 80 | Nonsynonymous: 70 | Stop Codon: 2

Protein Information

Protein Length: 1371 | Molecular Weight (kDa): 160.635

UniProt ID(s): O96228, Q689C8

PDB ID(s): None

Isoelectric Point: 8.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011049	Serralysin-like metalloprotease, C-terminal
PFam	N/A	N/A
Superfamily	SSF51120	Serralysin-like metalloprotease, C-terminal

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097