Product Description: rhoptry neck protein 6
SignalP Peptide: MQYFFLVFLAVLAKG
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1990225 | rhoptry neck |
| Component | GO:0020003 | symbiont-containing vacuole |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.95 |
| Trophozoite | expressed | 0.12 | 0.93 |
| Schizont | expressed | 2.34 | 0.22 |
| Gametocyte | possibly expressed | 0.31 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0214900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.937 | MFS: -2.316 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0311700)
Modification: Tagged | RMgm-4715
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96229
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 29 | 25 | 50 |
| disruptive | 69 | 173 | 88 | 207 |
| missense | 31 | 113 | 60 | 143 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 77 | 36 | 53 |
| disruptive | 109 | 363 | 142 | 298 |
| missense | 50 | 241 | 91 | 175 |
PlasmoDB Total SNPs: 483
Non-coding: 308 | Synonymous: 106 | Nonsynonymous: 69 | Stop Codon: 0
Protein Length: 950 | Molecular Weight (kDa): 112.2
UniProt ID(s): O96229
PDB ID(s): None
Isoelectric Point: 5.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19073187 | Characterisation of PfRON6, a Plasmodium falciparum rhoptry neck protein with anovel cysteine-rich domain. | Proellocks NI, Kats LM, ..., Coppel RL | 10.1016/j.ijpara.2008.11.002 |
| 37552754 | Knock-sideways by inducible ER retrieval enables a unique approach for studyingPlasmodium-secreted proteins | Fierro MA, Hussain T, Campin LJ, Beck JR | 10.1073/pnas.2308676120 |