Product Description: RING zinc finger protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0061630 | ubiquitin protein ligase activity |
| Process | GO:0016567 | protein ubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.10 | 0.94 |
| Schizont | expressed | 0.16 | 0.89 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0215100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.363 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0311900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0311900)
Modification: Disrupted | RMgm-1797
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I660
"Best" AlphaFill ligand hit: CPQ (n,n-bis(3-d-gluconamidopropyl)deoxycholamide, Local RMSD=0.72) with 4AYC (Global RMSD=17.35)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q13490 | Baculoviral IAP repeat-containing protein 2 | OrthoDB | AVPWpeptide isostere, 8peptide isostere, 10SM-131... | |
| Q60989 | E3 ubiquitin-protein ligase XIAP [124-240,C202A,C213G] | OrthoDB | US9345740, 1US9345740, 2US9345740, 3US9345740, 4... | |
| Q13489 | Baculoviral IAP repeat-containing protein 3 | OrthoDB | US8815927, SM-1266US8815927, SM-1259US8815927, SM-1265US8815927, SM-1267... | |
| P98170 | E3 ubiquitin-protein ligase XIAP | OrthoDB | Smac peptido-mimetic 1Smac peptido-mimetic 6cSmac peptido-mimetic 6dSmac peptido-mimetic 6e... | |
| Q96CA5 | Baculoviral IAP repeat-containing protein 7 | Homo sapiens | OrthoDB | CHEMBL5186855CHEMBL2431768CHEMBL5181541CHEMBL5175233... |
Ortholog Group (OrthoMCL): OG6_102038
Most Similar Human Ortholog: A0A3B3ISM3
TM-align score: 0.70 | RMSD: 3.36
Seq Identity: 0.24 | Length: 245 / 298
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102858 | mahogunin ring finger 1 |
| ENSG00000141576 | ring finger protein 157 |
Protein Length: 298 | Molecular Weight (kDa): 34.401
UniProt ID(s): Q8I660
PDB ID(s): None
Isoelectric Point: 6.94
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001841 | Zinc finger, RING-type |
| PFam | PF13920 | N/A |
| Superfamily | SSF57850 | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 16 | 5 | 16 |
| disruptive | 3 | 5 | 7 | 29 |
| missense | 3 | 5 | 6 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 23 | 15 | 26 |
| disruptive | 4 | 22 | 26 | 78 |
| missense | 4 | 20 | 17 | 57 |
PlasmoDB Total SNPs: 142
Non-coding: 123 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |