About Gene List

PF3D7_0215200

Genome location: Pf3D7_02_v3:625,082..627,710(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite not expressed 0.04 0.97
Schizont not expressed 0.03 0.98
Gametocyte not expressed 0.23 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0215200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.746 | MFS: -2.274 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0312000)

  • Relative Growth Rate: 1.01 ± 0.06
  • Confidence: 6.91

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0312000)

Modification: Disrupted | RMgm-1798

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96231

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106172

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 9 6 9
disruptive 4 5 7 25
missense 4 4 6 19

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 17 6 14
disruptive 7 22 26 49
missense 4 16 21 32

PlasmoDB Total SNPs: 127

Non-coding: 119 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 244 | Molecular Weight (kDa): 29.514

UniProt ID(s): O96231

PDB ID(s): None

Isoelectric Point: 9.61

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097