PF3D7_0215400

Genome location: Pf3D7_02_v3:634,417..639,395(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.46	0.77
Trophozoite	possibly expressed	0.50	0.71
Schizont	possibly expressed	0.69	0.61
Gametocyte	expressed	0.46	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0215400

Resistome Missense Mutations: G349R

Resistome Compounds with Missense Mutations: Lopinavir

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.789 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0312100)

Relative Growth Rate: 0.93 ± 0.18
Confidence: 4.87

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0312100)

Modification: Disrupted | RMgm-1799

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96233

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139461

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	28	24	52
disruptive	28	127	45	131
missense	16	91	40	104

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	77	30	55
disruptive	67	264	116	284
missense	40	184	83	187

PlasmoDB Total SNPs: 338

Non-coding: 159 | Synonymous: 107 | Nonsynonymous: 72 | Stop Codon: 0

Protein Information

Protein Length: 972 | Molecular Weight (kDa): 110.765

UniProt ID(s): O96233

PDB ID(s): None

Isoelectric Point: 7.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097