About Gene List

PF3D7_0215500

Genome location: Pf3D7_02_v3:639,847..643,411(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.34 0.83
Trophozoite expressed 0.33 0.80
Schizont expressed 0.28 0.82
Gametocyte expressed 0.39 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0215500

Resistome Missense Mutations: S463F

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 3 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.99 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0312200)

Modification: Disrupted | RMgm-1800

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96234

"Best" AlphaFill ligand hit: PXL (3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde, Local RMSD=0.60) with 6SU9 (Global RMSD=12.88)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532498

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 36 19 35
disruptive 32 109 55 161
missense 17 78 45 125

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 73 28 44
disruptive 62 276 111 263
missense 35 197 89 148

PlasmoDB Total SNPs: 287

Non-coding: 89 | Synonymous: 87 | Nonsynonymous: 111 | Stop Codon: 0

Protein Information

Protein Length: 764 | Molecular Weight (kDa): 89.327

UniProt ID(s): O96234

PDB ID(s): None

Isoelectric Point: 7.04

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097