Product Description: Golgi to ER traffic protein 2
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.22 | 0.89 |
| Trophozoite | expressed | 0.39 | 0.76 |
| Schizont | expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.33 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0215600
Resistome Missense Mutations: M364I
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.539 | MFS: -2.467 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1212200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96235
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 13 | 9 | 14 |
| disruptive | 27 | 59 | 18 | 84 |
| missense | 17 | 41 | 12 | 59 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 24 | 6 | 18 |
| disruptive | 54 | 129 | 53 | 134 |
| missense | 27 | 87 | 35 | 66 |
PlasmoDB Total SNPs: 110
Non-coding: 30 | Synonymous: 42 | Nonsynonymous: 38 | Stop Codon: 0
Protein Length: 403 | Molecular Weight (kDa): 48.274
UniProt ID(s): O96235
PDB ID(s): None
Isoelectric Point: 7.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34780541 | A conserved guided entry of tail-anchored pathway is involved in the traffickingof a subset of membrane proteins in Plasmodium falciparum. | Kumar T, Maitra S, Rahman A, Bhattacharjee S | 10.1371/journal.ppat.1009595 |
| 37882342 | Proteome-wide abundance profiling of yeast deletion strains for GET pathwaymembers using sample multiplexing | Gygi JS, Liu X, Levi BP, Paulo JA | 10.1002/pmic.202300303 |
| 29661846 | The GET pathway can increase the risk of mitochondrial outer membrane proteins tobe mistargeted to the ER | Vitali DG, Sinzel M, ..., Rapaport D | 10.1242/jcs.211110 |
| 37286562 | The GET pathway is a major bottleneck for maintaining proteostasis inSaccharomyces cerevisiae | Josefson R, Kumar N, ..., Nystrom T | 10.1038/s41598-023-35666-8 |
| 35231030 | The ER membrane complex (EMC) can functionally replace the Oxa1 insertase inmitochondria | Gungor B, Flohr T, Garg SG, Herrmann JM | 10.1371/journal.pbio.3001380 |
| 33443185 | Endoplasmic reticulum membrane receptors of the GET pathway are conservedthroughout eukaryotes | Asseck LY, Mehlhorn DG, ..., Grefen C | 10.1073/pnas.2017636118 |
| 37963916 | The GET insertase exhibits conformational plasticity and induces membranethinning | McDowell MA, Heimes M, ..., Sinning I | 10.1038/s41467-023-42867-2 |
| 32910895 | Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GETInsertase Complex | McDowell MA, Heimes M, ..., Sinning I | 10.1016/j.molcel.2020.08.012 |
| 25869254 | The emerging role of calcium-modulating cyclophilin ligand in posttranslationalinsertion of tail-anchored proteins into the endoplasmic reticulum membrane | Yamamoto Y, Sakisaka T | 10.1093/jb/mvv035 |
| 25368153 | Differential gradients of interaction affinities drive efficient targeting andrecycling in the GET pathway | Rome ME, Chio US, ..., Shan SO | 10.1073/pnas.1411284111 |
| 24392163 | WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane | Vilardi F, Stephan M, ..., Schwappach B | 10.1371/journal.pone.0085033 |
| 25043001 | The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane proteininsertase | Wang F, Chan C, Weir NR, Denic V | 10.1038/nature13471 |
| 26926495 | Get1p and Get2p are required for maintenance of mitochondrial morphology andnormal cardiolipin levels | Joshi AS, Fei N, Greenberg ML | 10.1093/femsyr/fow019 |
| 29673596 | The ER membrane insertase Get1/2 is required for efficient mitophagy in yeast | Onishi M, Nagumo S, Iwashita S, Okamoto K | 10.1016/j.bbrc.2018.04.114 |