About Gene List

PF3D7_0216100

Genome location: Pf3D7_02_v3:664,805..668,532(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.14 0.93
Trophozoite expressed 0.51 0.70
Schizont possibly expressed 0.15 0.90
Gametocyte not expressed 0.48 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0216100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.094 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3B7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533600

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 19 39 40 62
disruptive 32 107 63 158
missense 28 102 52 138

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 27 103 35 89
disruptive 68 300 150 343
missense 43 229 108 216

PlasmoDB Total SNPs: 124

Non-coding: 5 | Synonymous: 76 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 1182 | Molecular Weight (kDa): 144.124

UniProt ID(s): C6S3B7

PDB ID(s): None

Isoelectric Point: 10.24

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094