Product Description: Alba domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.54 | 0.74 |
| Trophozoite | expressed | 0.44 | 0.74 |
| Schizont | possibly expressed | 0.07 | 0.96 |
| Gametocyte | not expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0216200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.335 | MFS: -2.444 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96240
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105961
Most Similar Human Ortholog: O75817
TM-align score: 0.64 | RMSD: 3.34
Seq Identity: 0.20 | Length: 121 / 227
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000172336 | POP7 homolog, ribonuclease P/MRP subunit |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 9 | 6 | 19 |
| disruptive | 12 | 32 | 23 | 39 |
| missense | 10 | 28 | 22 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 23 | 13 | 14 |
| disruptive | 25 | 88 | 39 | 68 |
| missense | 17 | 72 | 34 | 42 |
PlasmoDB Total SNPs: 94
Non-coding: 63 | Synonymous: 17 | Nonsynonymous: 14 | Stop Codon: 0
Protein Length: 227 | Molecular Weight (kDa): 27.214
UniProt ID(s): O96240
PDB ID(s): None
Isoelectric Point: 9.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |