About Gene List

PF3D7_0216300

Genome location: Pf3D7_02_v3:670,210..675,095(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0042393 histone binding
Process GO:2000779 regulation of double-strand break repair

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.28 0.86
Trophozoite expressed 0.49 0.72
Schizont not expressed 0.06 0.97
Gametocyte possibly expressed 0.42 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0216300

Resistome Missense Mutations: N448H

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -2.93 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0313000)

  • Relative Growth Rate: 0.09 ± 0.05
  • Confidence: 7.40

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWT2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533753

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 18 77 57 98
disruptive 107 346 156 370
missense 62 241 123 291

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 36 162 71 102
disruptive 214 654 234 544
missense 117 455 168 325

PlasmoDB Total SNPs: 360

Non-coding: 78 | Synonymous: 142 | Nonsynonymous: 140 | Stop Codon: 0

Protein Information

Protein Length: 1381 | Molecular Weight (kDa): 165.342

UniProt ID(s): A0A143ZWT2

PDB ID(s): None

Isoelectric Point: 9.53

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094