About Gene List

PF3D7_0216500

Genome location: Pf3D7_02_v3:678,050..685,025(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite not expressed 0.29 0.84
Schizont possibly expressed 0.37 0.79
Gametocyte expressed 0.57 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0216500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.293 | #Insertions: 8

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0313200)

  • Relative Growth Rate: 1.03 ± 0.18
  • Confidence: 4.86

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0313200)

Modification: Disrupted | RMgm-1808

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96244

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532597

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 74 57 95
disruptive 53 244 139 295
missense 41 217 126 260

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 158 64 125
disruptive 125 538 221 500
missense 83 448 175 371

PlasmoDB Total SNPs: 261

Non-coding: 129 | Synonymous: 79 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1643 | Molecular Weight (kDa): 197.777

UniProt ID(s): O96244

PDB ID(s): None

Isoelectric Point: 10.03

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036322 WD40-repeat-containing domain superfamily
PFam N/A N/A
Superfamily SSF50978 WD40-repeat-containing domain superfamily

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097