PF3D7_0216600

Genome location: Pf3D7_02_v3:685,475..689,382(+)

Genome classification: Core

Function and Localization

Product Description: sugar transporter, putative

SignalP Peptide: MGIIKRILLLQIVLVLVLCCHRIRC

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.76	0.63
Trophozoite	expressed	0.41	0.75
Schizont	expressed	0.66	0.61
Gametocyte	expressed	0.52	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0216600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.821 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0313300)

Relative Growth Rate: 0.87 ± 0.13
Confidence: 5.42

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0313300)

Modification: Disrupted | RMgm-1809

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96245

"Best" AlphaFill ligand hit: DCM (2'-deoxycytidine-5'-monophosphate, Local RMSD=0.46) with 5XPD (Global RMSD=3.37)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100974

Most Similar Human Ortholog: Q9BRV3

TM-align score: 0.91 | RMSD: 1.86

Seq Identity: 0.21 | Length: 217 / 686

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000169241	solute carrier family 50 member 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	36	20	55
disruptive	23	93	44	147
missense	16	77	42	110

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	75	44	53
disruptive	42	229	120	250
missense	29	180	84	125

PlasmoDB Total SNPs: 251

Non-coding: 154 | Synonymous: 65 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 686 | Molecular Weight (kDa): 77.594

UniProt ID(s): O96245

PDB ID(s): None

Isoelectric Point: 5.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004316	SWEET sugar transporter
PFam	PF03083	SWEET sugar transporter
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104