Product Description: autophagy-related protein 11, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | nd | nd |
| Trophozoite | possibly expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | not expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0216700.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.998 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0313400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0313400)
Modification: Disrupted | RMgm-1810
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZXS2
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=1.26) with 3IO3 (Global RMSD=35.83)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 49 | 31 | 88 |
| disruptive | 28 | 129 | 78 | 211 |
| missense | 22 | 103 | 74 | 183 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 26 | 102 | 54 | 111 |
| disruptive | 57 | 273 | 141 | 323 |
| missense | 38 | 213 | 120 | 229 |
PlasmoDB Total SNPs: 339
Non-coding: 193 | Synonymous: 85 | Nonsynonymous: 59 | Stop Codon: 2
Protein Length: 1383 | Molecular Weight (kDa): 167.008
UniProt ID(s): A0A143ZXF2, Q8I659
PDB ID(s): None
Isoelectric Point: 6.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 35640768 | Mechanism of ER stress-mediated ER-phagy by CdTe-QDs in yeast cells | Wei F, Yang A, ..., Duan Y | 10.1016/j.toxlet.2022.05.010 |
| 36697253 | The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting ofthe Ppg1-Far complex | Onishi M, Kubota M, ..., Okamoto K | 10.26508/lsa.202201640 |
| 36283334 | The Dep1 protein: A new regulator of mitophagy in yeast | Camougrand N, Vigie P, ..., Bhatia-Kissova I | 10.1016/j.bbrc.2022.10.052 |
| 37659076 | Autophagy-mediated surveillance of Rim4-mRNA interaction safeguards programmedmeiotic translation | Zhang R, Feng W, Qian S, Wang F | 10.1016/j.celrep.2023.113051 |
| 37622373 | [Effect of mitophagy related genes on the antioxidant properties of Saccharomycescerevisiae] | Cheng W, Hou Q, ..., Wang J | 10.13345/j.cjb.220860 |
| 35255243 | The emerging roles of ATG1/ATG13 kinase complex in plants | Wang Q, Hou S | 10.1016/j.jplph.2022.153653 |
| 37927068 | Autophagy-mediated post-transcriptional surveillance of meiotic translation inSaccharomyces Cerevisiae | Zhang R, Feng W, Qian S, Wang F | 10.1080/15548627.2023.2276632 |
| 38316984 | A metabolite sensor subunit of the Atg1/ULK complex regulates selectiveautophagy | Gross AS, Ghillebert R, ..., Graef M | 10.1038/s41556-024-01348-4 |
| 35427192 | Atg1-mediated Atg11 phosphorylation is required for selective autophagy byregulating its association with receptor proteins | Yao W, Li Y, ..., Yi C | 10.1080/15548627.2022.2063494 |
| 35842014 | An overview of the molecular mechanisms of mitophagy in yeast | Schuster R, Okamoto K | 10.1016/j.bbagen.2022.130203 |