About Gene List

PF3D7_0216800

Genome location: Pf3D7_02_v3:695,848..699,564(-)

Genome classification: Core

Function and Localization

Product Description: TMEM121 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 14

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005615 extracellular space
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.10 0.93
Schizont possibly expressed 0.39 0.75
Gametocyte not expressed 0.04 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0216800

Resistome Missense Mutations: G395D

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.399 | MFS: -2.547 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96246

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127962

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 18 52 21 65
disruptive 109 137 49 134
missense 43 66 34 92

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 99 46 74
disruptive 146 223 88 206
missense 56 124 67 134

PlasmoDB Total SNPs: 339

Non-coding: 57 | Synonymous: 117 | Nonsynonymous: 165 | Stop Codon: 0

Protein Information

Protein Length: 1122 | Molecular Weight (kDa): 132.221

UniProt ID(s): O96246

PDB ID(s): None

Isoelectric Point: 9.19

Protein Domain Annotations:

Source Family ID Description
InterPro IPR032776 CECR6/TMEM121 family
PFam PF14997 CECR6/TMEM121 family
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097