About Gene List

PF3D7_0216900

Genome location: Pf3D7_02_v3:701,245..702,894(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite possibly expressed 0.08 0.95
Schizont expressed 0.15 0.90
Gametocyte possibly expressed 0.43 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0216900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.104 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0313600)

  • Relative Growth Rate: 0.90 ± 0.18
  • Confidence: 4.79

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0313600)

Modification: Disrupted | RMgm-4207

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96248

"Best" AlphaFill ligand hit: SSA (5'-o-(n-(l-seryl)-sulfamoyl)adenosine, Local RMSD=2.10) with 3QO8 (Global RMSD=29.06)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533774

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 14 6 33
disruptive 40 104 53 98
missense 22 75 38 75

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 37 14 39
disruptive 62 208 71 156
missense 31 149 56 98

PlasmoDB Total SNPs: 123

Non-coding: 0 | Synonymous: 66 | Nonsynonymous: 57 | Stop Codon: 0

Protein Information

Protein Length: 549 | Molecular Weight (kDa): 64.574

UniProt ID(s): O96248

PDB ID(s): None

Isoelectric Point: 4.81

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097