About Gene List

PF3D7_0217200

Genome location: Pf3D7_02_v3:709,474..715,607(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.13 0.93
Trophozoite possibly expressed 0.46 0.74
Schizont not expressed 0.20 0.87
Gametocyte possibly expressed 0.66 0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0217200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.198 | MFS: -2.728 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96253

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_128568

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 25 109 60 111
disruptive 96 320 175 358
missense 62 220 152 285

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 43 211 84 114
disruptive 190 660 285 567
missense 98 466 216 359

PlasmoDB Total SNPs: 346

Non-coding: 46 | Synonymous: 160 | Nonsynonymous: 140 | Stop Codon: 0

Protein Information

Protein Length: 1817 | Molecular Weight (kDa): 220.264

UniProt ID(s): O96253

PDB ID(s): None

Isoelectric Point: 9.75

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097