Product Description: AP-2 complex subunit sigma, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030131 | clathrin adaptor complex |
| Component | GO:0043231 | intracellular membrane-bounded organelle |
| Function | GO:0005515 | protein binding |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.06 | 0.96 |
| Schizont | not expressed | 0.14 | 0.91 |
| Gametocyte | not expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0217300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.198 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96254
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P62744 | AP-2 complex subunit sigma | Rattus | HOGENOM | Haloperidol, 1CHEMBL1689012CHEMBL1689009CHEMBL1689006... |
Ortholog Group (OrthoMCL): OG6_102766
Most Similar Human Ortholog: M0R0N4
TM-align score: 0.96 | RMSD: 0.98
Seq Identity: 0.40 | Length: 141 / 141
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000042753 | adaptor related protein complex 2 subunit sigma 1 |
Protein Length: 141 | Molecular Weight (kDa): 17.301
UniProt ID(s): O96254
PDB ID(s): None
Isoelectric Point: 9.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000804 | Clathrin adaptor complex, small chain |
| InterPro | IPR011012 | Longin-like domain superfamily |
| InterPro | IPR016635 | Adaptor protein complex, sigma subunit |
| InterPro | IPR022775 | AP complex, mu/sigma subunit |
| InterPro | IPR027156 | AP-2 complex subunit sigma |
| PFam | PF01217 | AP complex, mu/sigma subunit |
| Superfamily | SSF64356 | Longin-like domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 56
Non-coding: 50 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32098816 | The Plasmodium falciparum Artemisinin Susceptibility-Associated A P-2 Adaptin mu Subunit is Clathrin Independent and Essential for Schizont Maturation | Henrici RC, Edwards RL, ..., Sutherland CJ | 10.1128/mBio.02918-19 |
| 35486718 | FCHO controls AP2's initiating role in endocytosis through aPtdIns(4,5)P(2)-dependent switch | Zaccai NR, Kadlecova Z, ..., Traub LM | 10.1126/sciadv.abn2018 |
| 33008299 | Genome-wide identification and expression analysis of AP2/ERF transcriptionfactors in sugarcane (Saccharum spontaneum L.) | Li P, Chai Z, ..., Zhao X | 10.1186/s12864-020-07076-x |
| 37898053 | Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm | Zarringhalam K, Ye S, ..., Gubbels MJ | 10.1016/j.mib.2023.102383 |