PF3D7_0217600

Genome location: Pf3D7_02_v3:723,183..730,639(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.30	0.86
Trophozoite	not expressed	0.60	0.66
Schizont	possibly expressed	0.35	0.78
Gametocyte	not expressed	0.79	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0217600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.172 | MFS: -2.811 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96256

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=11.12) with 6JWQ (Global RMSD=19.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532958

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	92	45	114
disruptive	92	212	105	275
missense	45	146	87	196

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	172	73	93
disruptive	167	418	203	421
missense	80	280	147	260

PlasmoDB Total SNPs: 454

Non-coding: 203 | Synonymous: 132 | Nonsynonymous: 119 | Stop Codon: 0

Protein Information

Protein Length: 1710 | Molecular Weight (kDa): 203.917

UniProt ID(s): O96256

PDB ID(s): None

Isoelectric Point: 8.68

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011004	Trimeric LpxA-like superfamily
PFam	N/A	N/A
Superfamily	SSF51161	Trimeric LpxA-like superfamily

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097