PF3D7_0217700

Genome location: Pf3D7_02_v3:731,101..733,231(-)

Genome classification: Core

Function and Localization

Product Description: E2F-associated phosphoprotein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0217700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.668 | MFS: -3.009 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I657

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104741

Most Similar Human Ortholog: Q56P03

TM-align score: 0.47 | RMSD: 3.73

Seq Identity: 0.28 | Length: 132 / 234

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 83

Non-coding: 66 | Synonymous: 11 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 234 | Molecular Weight (kDa): 27.598

UniProt ID(s): Q8I657

PDB ID(s): None

Isoelectric Point: 4.59

Protein Domain Annotations: