Product Description: 40S ribosomal protein S26
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.00 | 0.55 |
| Trophozoite | expressed | 1.44 | 0.33 |
| Schizont | expressed | 0.25 | 0.85 |
| Gametocyte | expressed | 0.60 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0217800
Resistome Missense Mutations: K3N
Resistome Compounds with Missense Mutations: Atovaquone
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.169 | MFS: -2.899 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96258
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100814
Most Similar Human Ortholog: P62854
TM-align score: 0.92 | RMSD: 1.42
Seq Identity: 0.62 | Length: 106 / 107
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197728 | ribosomal protein S26 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 2 | 2 | 3 |
| disruptive | 1 | 0 | 0 | 2 |
| missense | 1 | 0 | 0 | 1 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 2 | 8 |
| disruptive | 1 | 3 | 7 | 11 |
| missense | 1 | 2 | 6 | 5 |
PlasmoDB Total SNPs: 67
Non-coding: 59 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 107 | Molecular Weight (kDa): 12.509
UniProt ID(s): O96258
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP, 6OKK
Isoelectric Point: 11.57
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000892 | Ribosomal protein S26e |
| PFam | PF01283 | Ribosomal protein S26e |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37013984 | Translation regulation of specific mRNAs by RPS26 C-terminal RNA-binding tailintegrates energy metabolism and AMPK-mTOR signaling | Havkin-Solomon T, Fraticelli D, ..., Dikstein R | 10.1093/nar/gkad238 |
| 33764298 | Reprogramming of translation in yeast cells impaired for ribosome recyclingfavors short, efficiently translated mRNAs | Gaikwad S, Ghobakhlou F, ..., Hinnebusch AG | 10.7554/eLife.64283 |