Product Description: thioesterase/thiol ester dehydrase-isomerase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0047617 | acyl-CoA hydrolase activity |
| Process | GO:0006637 | acyl-CoA metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.35 | 0.78 |
| Schizont | expressed | 0.18 | 0.88 |
| Gametocyte | possibly expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0217900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.997 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96259
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102325
Most Similar Human Ortholog: Q9Y305
TM-align score: 0.71 | RMSD: 3.78
Seq Identity: 0.17 | Length: 356 / 519
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000123130 | acyl-CoA thioesterase 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 18 | 13 | 37 |
| disruptive | 18 | 57 | 40 | 90 |
| missense | 18 | 56 | 40 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 50 | 20 | 41 |
| disruptive | 27 | 116 | 68 | 146 |
| missense | 26 | 109 | 65 | 101 |
PlasmoDB Total SNPs: 136
Non-coding: 117 | Synonymous: 9 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 519 | Molecular Weight (kDa): 60.598
UniProt ID(s): O96259
PDB ID(s): None
Isoelectric Point: 7.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR029069 | HotDog domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF54637 | HotDog domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |