PF3D7_0218100

Genome location: Pf3D7_02_v3:740,884..742,775(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	possibly expressed	0.24	0.85
Schizont	expressed	0.97	0.50
Gametocyte	expressed	0.29	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0218100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.145 | MFS: -2.86 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0314800)

Relative Growth Rate: 1.02 ± 0.09
Confidence: 6.19

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0314800)

Modification: Disrupted | RMgm-1815

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96261

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158742

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	4	28
disruptive	4	27	16	49
missense	4	26	15	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	36	10	16
disruptive	12	81	34	75
missense	6	69	26	49

PlasmoDB Total SNPs: 77

Non-coding: 62 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 355 | Molecular Weight (kDa): 43.508

UniProt ID(s): O96261

PDB ID(s): None

Isoelectric Point: 5.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097