PF3D7_0218200

Genome location: Pf3D7_02_v3:742,842..746,913(-)

Genome classification: Core

Function and Localization

Product Description: SUZ domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Function	GO:0008989	rRNA (guanine-N1-)-methyltransferase activity
Process	GO:0000027	ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	expressed	0.33	0.80
Schizont	possibly expressed	0.25	0.83
Gametocyte	not expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0218200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.565 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0314900)

Modification: Disrupted | RMgm-1816

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3B8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533292

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	47	30	55
disruptive	47	199	77	207
missense	30	140	59	168

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	102	32	60
disruptive	101	383	143	266
missense	47	284	119	159

PlasmoDB Total SNPs: 270

Non-coding: 108 | Synonymous: 116 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 807 | Molecular Weight (kDa): 94.691

UniProt ID(s): C6S3B8

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024771	SUZ domain
PFam	PF12752	SUZ domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
28288121	A genetic system to study Plasmodium falciparum protein function.	Birnbaum J, Flemming S, ..., Spielmann T	10.1038/nmeth.4223