Product Description: small nuclear ribonucleoprotein Sm D2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005685 | U1 snRNP |
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0005682 | U5 snRNP |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0071011 | precatalytic spliceosome |
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
| Process | GO:0000387 | spliceosomal snRNP assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.17 | 0.91 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0218500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.165 | MFS: -3.319 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0315200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0315200)
Modification: Disrupted | RMgm-1818
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96265
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102323
Most Similar Human Ortholog: P62316
TM-align score: 0.86 | RMSD: 1.56
Seq Identity: 0.63 | Length: 95 / 101
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125743 | small nuclear ribonucleoprotein D2 polypeptide |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 5 | 1 | 13 |
| disruptive | 0 | 5 | 3 | 3 |
| missense | 0 | 3 | 2 | 3 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 5 | 10 |
| disruptive | 4 | 7 | 9 | 25 |
| missense | 0 | 6 | 8 | 15 |
PlasmoDB Total SNPs: 215
Non-coding: 206 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 101 | Molecular Weight (kDa): 11.714
UniProt ID(s): O96265
PDB ID(s): None
Isoelectric Point: 10.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR027248 | Small nuclear ribonucleoprotein Sm D2 |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |