Product Description: pre-mRNA-processing protein 45, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.18 | 0.50 |
| Trophozoite | expressed | 0.65 | 0.64 |
| Schizont | expressed | 0.29 | 0.83 |
| Gametocyte | expressed | 0.66 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0218700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.175 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0315400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96267
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=5.05) with 3A4L (Global RMSD=24.20)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102543
Most Similar Human Ortholog: Q13573
TM-align score: 0.54 | RMSD: 5.21
Seq Identity: 0.26 | Length: 341 / 482
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100603 | SNW domain containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 23 | 16 | 28 |
| disruptive | 9 | 38 | 19 | 70 |
| missense | 9 | 35 | 19 | 66 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 56 | 17 | 36 |
| disruptive | 25 | 87 | 64 | 108 |
| missense | 19 | 70 | 52 | 83 |
PlasmoDB Total SNPs: 101
Non-coding: 81 | Synonymous: 14 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 482 | Molecular Weight (kDa): 57.526
UniProt ID(s): O96267
PDB ID(s): None
Isoelectric Point: 9.85
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004015 | SKI-interacting protein SKIP, SNW domain |
| InterPro | IPR017862 | SKI-interacting protein, SKIP |
| PFam | PF02731 | SKI-interacting protein SKIP, SNW domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15194481 | The human Ski-interacting protein functionally substitutes for the yeast PRP45gene | Figueroa JD, Hayman MJ | 10.1016/j.bbrc.2004.05.096 |
| 12359070 | Functional mapping of Saccharomyces cerevisiae Prp45 identifies the SNW domain asessential for viability | Martinkova K, Lebduska P, ..., Puta F | 10.1093/oxfordjournals.jbchem.a003257 |
| 28481201 | Functional mapping of yeast genomes by saturated transposition | Michel AH, Hatakeyama R, ..., Kornmann B | 10.7554/eLife.23570 |
| 26393790 | Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNABranch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysisin Yeast Spliceosomes | Schneider C, Agafonov DE, ..., Luhrmann R | 10.1371/journal.pgen.1005539 |