Product Description: saccharopine dehydrogenase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.5.1.7 (Saccharopine dehydrogenase (NAD(+), L-lysine-forming));1.5.1.9 (Saccharopine dehydrogenase (NAD(+), L-glutamate-forming))
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005811 | lipid droplet |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005886 | plasma membrane |
| Process | GO:0009247 | glycolipid biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.09 | 0.95 |
| Trophozoite | expressed | 0.10 | 0.94 |
| Schizont | possibly expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0219100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.843 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96268
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.5.1.7 | saccharopine dehydrogenase (NAD+, L-lysine-forming) | ATPADPAMPNMNNAD+NADHNADP+lysineoxalateadipateL-lysineL-valine... |
| 1.5.1.9 | saccharopine dehydrogenase (NAD+, L-glutamate-forming) | NH4ClL-glutamatehydroxylamine2-oxoglutarate2-AminoadipateSodium bisulfite3-acetylpyridine-NAD3-pyridine aldehyde-NADp-hydroxymercuribenzoate |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101495
Most Similar Human Ortholog: Q8NBX0
TM-align score: 0.85 | RMSD: 3.12
Seq Identity: 0.20 | Length: 404 / 426
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143653 | saccharopine dehydrogenase (putative) |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 25 | 9 | 29 |
| disruptive | 8 | 46 | 25 | 80 |
| missense | 8 | 45 | 23 | 70 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 45 | 21 | 29 |
| disruptive | 24 | 99 | 51 | 111 |
| missense | 17 | 86 | 43 | 72 |
PlasmoDB Total SNPs: 75
Non-coding: 48 | Synonymous: 14 | Nonsynonymous: 13 | Stop Codon: 0
Protein Length: 426 | Molecular Weight (kDa): 49.891
UniProt ID(s): O96268
PDB ID(s): None
Isoelectric Point: 9.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005097 | Saccharopine dehydrogenase, NADP binding domain |
| InterPro | IPR036291 | NAD(P)-binding domain superfamily |
| PFam | PF03435 | Saccharopine dehydrogenase, NADP binding domain |
| Superfamily | SSF51735 | NAD(P)-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |