Product Description: 40S ribosomal protein S30
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.15 | 0.92 |
| Trophozoite | possibly expressed | 0.19 | 0.88 |
| Schizont | possibly expressed | 0.05 | 0.97 |
| Gametocyte | possibly expressed | 0.07 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0219200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.125 | MFS: -3.066 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0315600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A0U2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101018
Most Similar Human Ortholog: P62861
TM-align score: 0.88 | RMSD: 1.05
Seq Identity: 0.66 | Length: 56 / 58
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000149806 | FAU ubiquitin like and ribosomal protein S30 fusion |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 88
Non-coding: 85 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 58 | Molecular Weight (kDa): 6.488
UniProt ID(s): A0A144A0U2, O96269
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP, 6OKK
Isoelectric Point: 12.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006846 | Ribosomal protein S30 |
| PFam | PF04758 | Ribosomal protein S30 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 11054821 | Analysis of 114 kb of DNA sequence from fission yeast chromosome 2 immediatelycentromere-distal to his5 | Xiang Z, Moore K, ..., Aves SJ | 10.1002/1097-0061(200011)16:15<1405::AID-YEA625>3.0.CO;2-H |
| 8662789 | The yeast homolog of mammalian ribosomal protein S30 is expressed from aduplicated gene without a ubiquitin-like protein fusion sequence. Evolutionaryimplications | Baker RT, Williamson NA, Wettenhall RE | 10.1074/jbc.271.23.13549 |
| 36602409 | Transgenic RFP-RPS-30(UbL) strain of the nematode Caenorhabditis elegans as abiomonitor for environmental pollutants | Sun W, Liu H, ..., Yan B | 10.1002/tox.23732 |
| 18390649 | Genomewide location analysis of Candida albicans Upc2p, a regulator of sterolmetabolism and azole drug resistance | Znaidi S, Weber S, ..., Raymond M | 10.1128/EC.00070-08 |
| 34487827 | Amphioxus ribosomal proteins RPS15, RPS18, RPS19 and RPS30-precursor act asimmune effectors via killing or agglutinating bacteria | Chen C, Yuan J, ..., Gao Z | 10.1016/j.fsi.2021.09.001 |