About Gene List

PF3D7_0219400

Genome location: Pf3D7_02_v3:774,447..776,838(+)

Genome classification: Core

Function and Localization

Product Description: ribosome associated membrane protein RAMP4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Process GO:0030968 endoplasmic reticulum unfolded protein response
Process GO:0006486 protein glycosylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0219400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.146 | MFS: -3.231 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0315800)

  • Relative Growth Rate: 0.97 ± 0.11
  • Confidence: 5.78

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0315800)

Modification: Disrupted | RMgm-1821

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I655

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103949

Most Similar Human Ortholog: Q8N6R1

TM-align score: 0.52 | RMSD: 2.90

Seq Identity: 0.18 | Length: 50 / 101

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000151778 stress associated endoplasmic reticulum protein family member 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 1 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 185

Non-coding: 178 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 101 | Molecular Weight (kDa): 11.576

UniProt ID(s): Q8I655

PDB ID(s): None

Isoelectric Point: 11.15

Protein Domain Annotations:

Source Family ID Description
InterPro IPR010580 Stress-associated endoplasmic reticulum protein
PFam PF06624 Stress-associated endoplasmic reticulum protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097