About Gene List

PF3D7_0220500

Genome location: Pf3D7_02_v3:823,293..825,588(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp2), unknown function

SignalP Peptide: MLHVYFKIFYIAVLFGLIFLNQNVCT

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.14 0.94
Trophozoite not expressed 0.14 0.94
Schizont expressed 0.75 0.69
Gametocyte not expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0220500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.119 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q7KWI6

"Best" AlphaFill ligand hit: GM6 (gm6001, Local RMSD=0.74) with 1PWU (Global RMSD=43.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146099

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 2 2 5
disruptive 4 5 1 9
missense 4 5 1 8

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 5 5 2
disruptive 6 8 4 17
missense 6 5 3 13

PlasmoDB Total SNPs: 112

Non-coding: 63 | Synonymous: 39 | Nonsynonymous: 9 | Stop Codon: 1

Protein Information

Protein Length: 271 | Molecular Weight (kDa): 33.01

UniProt ID(s): Q7KWI6, Q8WSS5

PDB ID(s): None

Isoelectric Point: 7

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12