Product Description: Plasmodium exported protein, unknown function
SignalP Peptide: MNFCSFIFLFTLTLRVLFA
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043657 | host cell |
| Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | nd | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | not expressed | nd | 1.00 |
| Gametocyte | not expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0221000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.997 | MFS: -2.773 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZXW4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 4 | 4 | 10 |
| disruptive | 51 | 51 | 19 | 44 |
| missense | 32 | 32 | 13 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 15 | 4 | 14 |
| disruptive | 60 | 81 | 40 | 75 |
| missense | 36 | 52 | 23 | 42 |
PlasmoDB Total SNPs: 123
Non-coding: 25 | Synonymous: 37 | Nonsynonymous: 56 | Stop Codon: 5
Protein Length: 302 | Molecular Weight (kDa): 34.697
UniProt ID(s): A0A143ZXW4
PDB ID(s): None
Isoelectric Point: 8.36
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16507167 | Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. | Sargeant TJ, Marti M, ..., Cowman AF | 10.1186/gb-2006-7-2-r12 |