Genome location: Pf3D7_02_v3:860,466..861,504(+)
Genome classification: SubtelomericHypervariable
Product Description: stevor
SignalP Peptide: MNIYYINMLVMSILLIVLFLSYNVNN
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.00 | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0221400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.861 | MFS: -2.451 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96283
"Best" AlphaFill ligand hit: NAI (nadh, Local RMSD=16.96) with 4XSH (Global RMSD=17.14)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 7 | 2 | 11 |
| disruptive | 26 | 38 | 13 | 47 |
| missense | 21 | 30 | 10 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 8 | 8 | 9 |
| disruptive | 41 | 62 | 29 | 66 |
| missense | 34 | 44 | 24 | 41 |
PlasmoDB Total SNPs: 107
Non-coding: 15 | Synonymous: 58 | Nonsynonymous: 31 | Stop Codon: 3
Protein Length: 307 | Molecular Weight (kDa): 35.409
PDB ID(s): None
Isoelectric Point: 9.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006374 | Variant surface antigen Stevor |
| PFam | PF17410 | Variant surface antigen Stevor |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 12477793 | Small variant STEVOR antigen is uniquely located within Maurer's clefts inPlasmodium falciparum-infected red blood cells. | Kaviratne M, Khan SM, Jarra W, Preiser PR | 10.1128/EC.1.6.926-935.2002 |
| 25011110 | STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. | Niang M, Bei AK, ..., Preiser PR | 10.1016/j.chom.2014.06.004 |