Genome location: Pf3D7_02_v3:878,211..879,540(-)
Genome classification: SubtelomericHypervariable
Product Description: Pfmc-2TM Maurer's cleft two transmembrane protein
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Process | GO:0042000 | translocation of peptides or proteins into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | possibly expressed | 0.04 | 0.98 |
| Schizont | possibly expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0222100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.777 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96287
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=9.15) with 3TD7 (Global RMSD=19.02)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 257
Non-coding: 64 | Synonymous: 67 | Nonsynonymous: 126 | Stop Codon: 0
Protein Length: 229 | Molecular Weight (kDa): 27.063
UniProt ID(s): O96287
PDB ID(s): None
Isoelectric Point: 10.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15140830 | A Plasmodium gene family encoding Maurer's cleft membrane proteins: structuralproperties and expression profiling. | Sam-Yellowe TY, Florens L, ..., Yates JR 3rd | 10.1101/gr.2126104 |
| 24045696 | Proteomic analysis of detergent-resistant membrane microdomains in trophozoiteblood stage of the human malaria parasite Plasmodium falciparum. | Yam XY, Birago C, ..., Ponzi M | 10.1074/mcp.M113.029272 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33916455 | Trafficking and Association of Plasmodium falciparum MC-2TM with the Maurer'sClefts | Yadavalli R, Peterson JW, Drazba JA, Sam-Yellowe TY | 10.3390/pathogens10040431 |