About Gene List

PF3D7_0222800

Genome location: Pf3D7_02_v3:899,430..900,445(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MNMYYVKMLLFAFLINTLVLP

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed nd 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0222800

Resistome Missense Mutations: T43A, N46K, H61Y, K83Q, V94L, G173R, C180G

Resistome Compounds with Missense Mutations: AN13762, GNF707, KAE678/NITD678, MMV019066

Resistome # Samples with Disruptive Mutations: 7 (7 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.256 | MFS: -2.511 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96291

"Best" AlphaFill ligand hit: G39 ((3r,4r,5s)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, Local RMSD=0.07) with 2YA8 (Global RMSD=18.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 477

Non-coding: 41 | Synonymous: 95 | Nonsynonymous: 338 | Stop Codon: 3

Protein Information

Protein Length: 304 | Molecular Weight (kDa): 34

UniProt ID(s): O96291, Q2XR49, Q2XR50, Q2XR51, Q2XR52, Q2XR53, Q2XR54, Q2XR55, Q2XR58

PDB ID(s): None

Isoelectric Point: 8.27

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
PFam PF17410 Variant surface antigen Stevor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
12477793 Small variant STEVOR antigen is uniquely located within Maurer's clefts inPlasmodium falciparum-infected red blood cells. Kaviratne M, Khan SM, Jarra W, Preiser PR 10.1128/EC.1.6.926-935.2002
15961998 Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infectederythrocytes. Przyborski JM, Miller SK, ..., Lanzer M 10.1038/sj.emboj.7600720
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004