Genome location: Pf3D7_03_v3:36,965..44,482(+)
Genome classification: SubtelomericHypervariable
Product Description: erythrocyte membrane protein 1, PfEMP1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.05 | 0.97 |
| Schizont | expressed | 0.12 | 0.91 |
| Gametocyte | expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0300100
Resistome Missense Mutations: A34V, Y41H, Y41C, Q44E, R128S, Y136F, K138N, D142H, G233E, D235A, T247S, A309G, D311E, E384V, D391A, K392E, K392N, N1941K, K1948R, K1948N, V2172A
Resistome Compounds with Missense Mutations: AN13762, KAE678/NITD678, Proguanil
Resistome # Samples with Disruptive Mutations: 4 (4 missense, 4 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.144 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97324
"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=1.00) with 5MZA (Global RMSD=5.74)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 2586
Non-coding: 381 | Synonymous: 665 | Nonsynonymous: 1520 | Stop Codon: 20
Protein Length: 2209 | Molecular Weight (kDa): 250.477
UniProt ID(s): A0A191VYZ9, A0A191VZ66, A0A191VZ67, A0A191VZ79, A0A191VZ84, A0A5P1A046, A0A5P1A062, A0A5P1A099, A0A5P1A0D6, A0A5P1A0G6, A0A5P1A120, A0A5P1A1B5, A0A5P1A1Q6, A0A5P1A1R9, A0A5P1A2I4, O97324
PDB ID(s): None
Isoelectric Point: 5.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004258 | Duffy-binding-like domain |
| InterPro | IPR008602 | Duffy-antigen binding |
| InterPro | IPR029210 | Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment |
| InterPro | IPR029211 | Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment |
| InterPro | IPR041480 | Cysteine-rich interdomain region 1 gamma |
| PFam | PF03011 | Duffy-binding-like domain |
| PFam | PF05424 | Duffy-antigen binding |
| PFam | PF15445 | Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment |
| PFam | PF15447 | Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment |
| PFam | PF18562 | Cysteine-rich interdomain region 1 gamma |
| Superfamily | SSF140924 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19463825 | A var gene promoter implicated in severe malaria nucleates silencing and isregulated by 3' untranslated region and intronic cis-elements. | Muhle RA, Adjalley S, ..., Fidock DA | 10.1016/j.ijpara.2009.05.001 |