About Gene List

PF3D7_0300400

Genome location: Pf3D7_03_v3:52,280..53,273(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MKMYYLKMLLFTFLINTLILP

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0033644 host cell membrane
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed nd 1.00
Trophozoite possibly expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed nd 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0300400

Resistome Missense Mutations: E89K, Y102H

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.561 | MFS: -2.368 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U5L9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 526

Non-coding: 51 | Synonymous: 152 | Nonsynonymous: 318 | Stop Codon: 5

Protein Information

Protein Length: 296 | Molecular Weight (kDa): 33.361

UniProt ID(s): O96489, Q9U5L9

PDB ID(s): None

Isoelectric Point: 9.04

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
PFam PF17410 Variant surface antigen Stevor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004
31363031 Dissecting the Gene Expression, Localization, Membrane Topology, and Function ofthe Plasmodium falciparum S TEVOR Protein Family Wichers JS, Scholz JAM, ..., Bachmann A 10.1128/mBio.01500-19