About Gene List

PF3D7_0301100

Genome location: Pf3D7_03_v3:76,494..77,474(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp13), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite not expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0301100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.204 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97335

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215319

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 11 5 9
disruptive 14 47 21 55
missense 12 43 18 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 14 5 18
disruptive 23 88 33 88
missense 20 72 28 61

PlasmoDB Total SNPs: 60

Non-coding: 33 | Synonymous: 13 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 256 | Molecular Weight (kDa): 30.399

UniProt ID(s): O97335

PDB ID(s): None

Isoelectric Point: 10.31

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12