Product Description: epoxide hydrolase 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0044538 | host cell periphery |
| Function | GO:0004301 | epoxide hydrolase activity |
| Function | GO:0016787 | hydrolase activity |
| Function | GO:0030507 | spectrin binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.29 | 0.86 |
| Trophozoite | expressed | 0.16 | 0.91 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0301300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.981 | MFS: -1.86 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9Y013
"Best" AlphaFill ligand hit: OCT (n-octane, Local RMSD=0.13) with 7Q4J (Global RMSD=4.86)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q8R2Y0 | Monoacylglycerol lipase ABHD6 | Mus musculus | OrthoMCL BLAST | LY2183240US10781211, Example 21US10781211, Example 22US10781211, Example 25... |
| Q9BV23 | Monoacylglycerol lipase ABHD6 | OrthoMCL BLAST | US10662159, Example 1US10662159, Example 4US10662159, Example 8US10662159, Example 9... |
Ortholog Group (OrthoMCL): OG6_101137
Most Similar Human Ortholog: C9JBM3
TM-align score: 0.78 | RMSD: 2.26
Seq Identity: 0.27 | Length: 114 / 437
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000011198 | abhydrolase domain containing 5, lysophosphatidic acid acyltransferase |
| ENSG00000100439 | abhydrolase domain containing 4, N-acyl phospholipase B |
Protein Length: 437 | Molecular Weight (kDa): 50.511
UniProt ID(s): Q9Y013
PDB ID(s): None
Isoelectric Point: 7.54
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000073 | Alpha/beta hydrolase fold-1 |
| InterPro | IPR029058 | Alpha/Beta hydrolase fold |
| PFam | PF00561 | Alpha/beta hydrolase fold-1 |
| Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 9 | 4 | 14 |
| disruptive | 11 | 26 | 17 | 46 |
| missense | 11 | 23 | 15 | 42 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 16 | 10 | 18 |
| disruptive | 17 | 74 | 43 | 82 |
| missense | 11 | 61 | 35 | 62 |
PlasmoDB Total SNPs: 87
Non-coding: 73 | Synonymous: 6 | Nonsynonymous: 8 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 27795395 | Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection | Spillman NJ, Dalmia VK, Goldberg DE | 10.1128/mBio.01538-16 |