About Gene List

PF3D7_0301400

Genome location: Pf3D7_03_v3:85,289..86,678(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.16 0.93
Trophozoite expressed 0.53 0.69
Schizont expressed 0.07 0.96
Gametocyte possibly expressed 0.16 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0301400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.171 | MFS: -2.773 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H467

"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=17.17) with 6UHX (Global RMSD=17.63)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533459

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 3 5 0
disruptive 16 29 12 34
missense 15 26 11 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 4 5 8
disruptive 23 48 24 72
missense 20 38 21 51

PlasmoDB Total SNPs: 51

Non-coding: 34 | Synonymous: 3 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 243 | Molecular Weight (kDa): 29.638

UniProt ID(s): C0H467

PDB ID(s): None

Isoelectric Point: 4.23

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12