About Gene List

PF3D7_0301600 (GEXP21)

Genome location: Pf3D7_03_v3:91,001..94,089(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp1), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.26 0.46
Trophozoite expressed 0.54 0.72
Schizont expressed 0.19 0.89
Gametocyte expressed 0.29 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0301600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -2.439 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H468

"Best" AlphaFill ligand hit: GM6 (gm6001, Local RMSD=0.09) with 1PWU (Global RMSD=24.15)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533535

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 30 13 17
disruptive 40 82 46 86
missense 34 71 43 66

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 44 19 29
disruptive 56 147 79 184
missense 48 118 61 128

PlasmoDB Total SNPs: 169

Non-coding: 64 | Synonymous: 51 | Nonsynonymous: 53 | Stop Codon: 1

Protein Information

Protein Length: 732 | Molecular Weight (kDa): 87.508

UniProt ID(s): C0H468

PDB ID(s): None

Isoelectric Point: 4.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332