Product Description: EMP1 trafficking protein PTP7
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0043657 | host cell |
| Component | GO:0030430 | host cell cytoplasm |
| Function | GO:0005515 | protein binding |
| Process | GO:0044650 | adhesion of symbiont to host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.33 | 0.85 |
| Trophozoite | expressed | 0.87 | 0.54 |
| Schizont | expressed | 0.24 | 0.86 |
| Gametocyte | not expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0301700
Resistome Missense Mutations: P110T
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.898 | MFS: -2.273 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97336
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 2 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 2 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 190
Non-coding: 175 | Synonymous: 6 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 317 | Molecular Weight (kDa): 37.389
UniProt ID(s): O97336
PDB ID(s): None
Isoelectric Point: 8.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 25850860 | The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins. | Schulze J, Kwiatkowski M, ..., Pick C | 10.1111/mmi.13024 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 33774908 | Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. | Jonsdottir TK, Counihan NA, ..., Gilson PR | 10.1111/cmi.13332 |
| 21887652 | The activity of a small lytic peptide PTP-7 on Staphylococcus aureus biofilms | Kharidia R, Liang JF | 10.1007/s12275-011-1013-5 |
| 35930605 | Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer'sclefts vesiculation, host cell remodeling defects, and loss of surfacepresentation of EMP1 | Carmo OMS, Shami GJ, ..., Dixon MWA | 10.1371/journal.ppat.1009882 |