PF3D7_0301800

Genome location: Pf3D7_03_v3:103,118..105,748(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.21	0.49
Trophozoite	possibly expressed	0.20	0.89
Schizont	expressed	0.16	0.91
Gametocyte	not expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0301800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.32 | MFS: -2.725 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0700700)

Relative Growth Rate: 0.85 ± 0.13
Confidence: 5.44

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0700700)

Modification: Disrupted | RMgm-2161

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97332

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532302

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	15	4	6
disruptive	11	17	7	20
missense	11	16	7	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	15	7	13
disruptive	13	41	19	38
missense	12	34	15	27

PlasmoDB Total SNPs: 77

Non-coding: 56 | Synonymous: 9 | Nonsynonymous: 10 | Stop Codon: 2

Protein Information

Protein Length: 257 | Molecular Weight (kDa): 30.785

UniProt ID(s): O97332

PDB ID(s): None

Isoelectric Point: 8.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16507167	Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites.	Sargeant TJ, Marti M, ..., Cowman AF	10.1186/gb-2006-7-2-r12
31631203	A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum.	Das D, Krishnan SR, Roy A, Bulusu G	10.1039/c9mo00124g