PF3D7_0301900

Genome location: Pf3D7_03_v3:105,433..107,500(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	not expressed	0.44	0.73
Schizont	not expressed	0.16	0.90
Gametocyte	not expressed	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0301900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -3.159 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0400900)

Relative Growth Rate: 0.09 ± 0.04
Confidence: 7.94

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97333

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133214

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	17	3	21
disruptive	17	26	12	42
missense	16	25	12	32

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	23	10	19
disruptive	20	45	27	66
missense	19	39	24	36

PlasmoDB Total SNPs: 118

Non-coding: 94 | Synonymous: 13 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 398 | Molecular Weight (kDa): 48.066

UniProt ID(s): O97333

PDB ID(s): None

Isoelectric Point: 9.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095