Product Description: pre-mRNA-splicing factor PRP46, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex |
| Component | GO:0000974 | Prp19 complex |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005681 | spliceosomal complex |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.79 | 0.64 |
| Trophozoite | expressed | 0.72 | 0.60 |
| Schizont | expressed | 0.22 | 0.86 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0302000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -3.009 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97334
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.06) with 6Y7O (Global RMSD=4.19)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101928
Most Similar Human Ortholog: H0YAA2
TM-align score: 0.85 | RMSD: 2.26
Seq Identity: 0.36 | Length: 101 / 600
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000171566 | pleiotropic regulator 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 30 | 9 | 27 |
| disruptive | 17 | 49 | 24 | 62 |
| missense | 13 | 43 | 20 | 57 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 34 | 38 | 12 | 25 |
| disruptive | 27 | 86 | 46 | 85 |
| missense | 16 | 72 | 43 | 65 |
PlasmoDB Total SNPs: 65
Non-coding: 25 | Synonymous: 28 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 600 | Molecular Weight (kDa): 69.573
UniProt ID(s): O97334
PDB ID(s): None
Isoelectric Point: 8.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR020472 | G-protein beta WD-40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |