Product Description: CDGSH iron-sulfur domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.12 | 0.92 |
| Schizont | possibly expressed | 0.08 | 0.95 |
| Gametocyte | not expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0302700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.12 | MFS: -2.948 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9NDU7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| B0K020 | CDGSH iron-sulfur domain-containing protein 1 | OrthoDB, OrthoMCL BLAST | RosiglitazonePioglitazoneCHEMBL602048 | |
| Q9NZ45 | CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens | OrthoDB, OrthoMCL BLAST | US8877795, 12CHEMBL230515CHEMBL3901608CHEBI:3962... |
| Q8N5K1 | CDGSH iron-sulfur domain-containing protein 2 | OrthoDB, OrthoMCL BLAST | PioglitazoneRosiglitazone |
Protein Length: 152 | Molecular Weight (kDa): 18.359
UniProt ID(s): Q9NDU7
PDB ID(s): None
Isoelectric Point: 9.46
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018967 | Iron sulphur-containing domain, CDGSH-type |
| PFam | PF09360 | Iron sulphur-containing domain, CDGSH-type |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 7 | 3 | 12 |
| disruptive | 1 | 13 | 7 | 17 |
| missense | 1 | 13 | 6 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 21 | 8 | 15 |
| disruptive | 1 | 34 | 9 | 43 |
| missense | 1 | 28 | 7 | 33 |
PlasmoDB Total SNPs: 42
Non-coding: 34 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |