Product Description: exportin-1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0005049 | nuclear export signal receptor activity |
| Process | GO:0006611 | protein export from nucleus |
| Process | GO:0046825 | regulation of protein export from nucleus |
| Process | GO:0000055 | ribosomal large subunit export from nucleus |
| Process | GO:0000056 | ribosomal small subunit export from nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.87 |
| Trophozoite | expressed | 0.70 | 0.61 |
| Schizont | expressed | 0.34 | 0.79 |
| Gametocyte | possibly expressed | 0.46 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0302900
Resistome Missense Mutations: F178Y
Resistome Compounds with Missense Mutations: AN13762, AN13956
Resistome # Samples with Disruptive Mutations: 5 (5 missense, 5 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.224 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0401500)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0401500)
Modification: Disrupted | RMgm-501
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77312
"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.42) with 7CND (Global RMSD=3.86)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O14980 | Exportin-1 | Homo sapiens | HOGENOM, OMA, OrthoDB | ostholeCHEMBL1084286LEPTOMYCIN BCHEMBL4077955... |
Ortholog Group (OrthoMCL): OG6_101697
Most Similar Human Ortholog: A0A7I2V3N0
TM-align score: 0.93 | RMSD: 2.46
Seq Identity: 0.33 | Length: 720 / 1254
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000082898 | exportin 1 |
Protein Length: 1254 | Molecular Weight (kDa): 147.938
UniProt ID(s): O77312
PDB ID(s): None
Isoelectric Point: 5.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001494 | Importin-beta, N-terminal domain |
| InterPro | IPR013598 | Exportin-1/Importin-beta-like |
| InterPro | IPR014877 | Exportin-1, C-terminal |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR040485 | Exportin-1, repeat 3 |
| InterPro | IPR041235 | Exportin-1, repeat 2 |
| PFam | PF03810 | Importin-beta, N-terminal domain |
| PFam | PF08389 | Exportin-1/Importin-beta-like |
| PFam | PF08767 | Exportin-1, C-terminal |
| PFam | PF18784 | Exportin-1, repeat 2 |
| PFam | PF18787 | Exportin-1, repeat 3 |
| Superfamily | SSF48371 | Armadillo-type fold |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 65 | 40 | 81 |
| disruptive | 10 | 27 | 24 | 85 |
| missense | 9 | 25 | 23 | 66 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 215 | 42 | 67 |
| disruptive | 14 | 115 | 65 | 248 |
| missense | 12 | 78 | 52 | 145 |
PlasmoDB Total SNPs: 214
Non-coding: 157 | Synonymous: 43 | Nonsynonymous: 14 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |