Product Description: CLP1 P-loop domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity |
| Process | GO:0006396 | RNA processing |
| Process | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.10 | 0.95 |
| Trophozoite | possibly expressed | 0.26 | 0.84 |
| Schizont | expressed | 0.81 | 0.57 |
| Gametocyte | not expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0303100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.478 | #Insertions: 6
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0401700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0401700)
Modification: Disrupted | RMgm-1833
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77314
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103124
Most Similar Human Ortholog: Q5SY16
TM-align score: 0.44 | RMSD: 5.32
Seq Identity: 0.18 | Length: 371 / 1441
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000162408 | nucleolar protein 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 79 | 44 | 77 |
| disruptive | 68 | 260 | 127 | 229 |
| missense | 55 | 233 | 113 | 206 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 137 | 59 | 91 |
| disruptive | 117 | 488 | 167 | 343 |
| missense | 92 | 415 | 148 | 259 |
PlasmoDB Total SNPs: 281
Non-coding: 145 | Synonymous: 77 | Nonsynonymous: 59 | Stop Codon: 0
Protein Length: 1441 | Molecular Weight (kDa): 170.175
UniProt ID(s): O77314
PDB ID(s): None
Isoelectric Point: 7.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR032319 | Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain |
| PFam | PF16575 | Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |