Product Description: lipin, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.4 (Phosphatidate phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005634 | nucleus |
| Function | GO:0008195 | phosphatidate phosphatase activity |
| Process | GO:0044255 | cellular lipid metabolic process |
| Process | GO:0046473 | phosphatidic acid metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 1.00 | 0.50 |
| Schizont | expressed | 2.36 | 0.13 |
| Gametocyte | expressed | 1.15 | 0.43 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0303200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.409 | MFS: -2.458 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0401800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77317
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.4 | phosphatidate phosphatase | ATPGTPCTPNEMSDSNaFEDTAPCMBDMSOHgCl2CuSO4ZnCl2... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100990
Most Similar Human Ortholog: C9J278
TM-align score: 0.70 | RMSD: 1.76
Seq Identity: 0.04 | Length: 25 / 1162
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101577 | lipin 2 |
| ENSG00000132793 | lipin 3 |
| ENSG00000134324 | lipin 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 76 | 35 | 64 |
| disruptive | 46 | 123 | 73 | 148 |
| missense | 25 | 107 | 63 | 109 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 134 | 55 | 64 |
| disruptive | 83 | 263 | 116 | 250 |
| missense | 41 | 207 | 89 | 156 |
PlasmoDB Total SNPs: 265
Non-coding: 114 | Synonymous: 93 | Nonsynonymous: 58 | Stop Codon: 0
Protein Length: 1162 | Molecular Weight (kDa): 134.738
UniProt ID(s): O77317
PDB ID(s): None
Isoelectric Point: 9.57
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007651 | Lipin, N-terminal |
| InterPro | IPR013209 | Lipin/Ned1/Smp2 (LNS2) |
| InterPro | IPR026058 | LIPIN family |
| InterPro | IPR031315 | LNS2/PITP |
| InterPro | IPR031703 | Lipin, middle domain |
| InterPro | IPR036412 | HAD-like superfamily |
| PFam | PF04571 | Lipin, N-terminal |
| PFam | PF08235 | Lipin/Ned1/Smp2 (LNS2) |
| PFam | PF16876 | Lipin, middle domain |
| Superfamily | SSF56784 | HAD-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34001876 | Toxoplasma LIPIN is essential in channeling host lipid fluxes through membranebiogenesis and lipid storage. | Dass S, Shunmugam S, ..., Botte CY | 10.1038/s41467-021-22956-w |